Opportunities in Nanostructured Materials: Biomedical, Pharmaceutical and Cosmetic

Report Highlights

• The world market for nanoparticulate materials in biomedical, pharmaceutical and cosmetic applications reached $97.0 million in 2000. This figure represents the value of inorganic nanoparticles used as, or to produce antimicrobial agents, biological labels, separations media, carriers for drug delivery, sunscreens, etc.
• Two applications that have been undergoing development and commercialization for a decade account for more than 90% of this market.
• Growing at an average annual rate (AAGR) of 8.3%, this market is expected to reach nearly $145 million in 2005.
• The sun-protection market has the greatest near-term revenue potential, while drug-carrier applications will be slowest to penetrate the market.
• Key to many bioapplications is the comparable size scale of nanocrystals and biological materials, such as antibodies and proteins.

INTRODUCTION

REASON FOR STUDY AND ITS IMPORTANCE

"Nano-", once a seldom-used prefix found in the back of scientific textbooks, has moved into the industrial mainstream. Literally, "nano" represents 0.000000001, or 10^-9, an extremely small quantity with enormous implications for the miniaturization-driven technology of the twenty-first century. Within the past two decades, a variety of terms sharing the prefix "nano-", such as nanoparticle, nanomaterial, nanophase, and nanostructured, have emerged to describe certain materials, technologies, and even es; in fact, several firms listed on the NASDAQ stock exchange use the prefix "nano-" in their company names. Although nano may not yet be a household word, it is indeed well known within (and increasingly vital to) the advanced materials community and high-technology sector. In part due to the credibility and visibility imparted by the National Nanotechnology Initiative in early 2000, nanoterminology has become trendy, popular, and representative of all that is high-tech in the materials world.

In 1997, Communications Co., Inc. (BCC) published a seminal technical-market study of the nanomaterials field — a report that defined the scope of the industry for the first time. Since then, the industry has witnessed many changes: new entrants into the ; production scale-up efforts; new commercialization strategies; and technological advancements. In light of these developments, BCC opted to take a fresh look at the industry and reevaluate the existing and potential markets for nanoparticulate materials. The culmination of that research is a three-volume series of reports — without question the most comprehensive source of industry information and technical market data available today on nanoparticulate materials.

OBJECTIVES OF THIS STUDY AND ITS CONTRIBUTION

This study fills a gap in the published literature on nanoparticles and nanostructured materials. Although numerous technical papers and overview articles address various aspects of nanomaterial technology, the literature lacks a comprehensive, up-to-date, and realistic technical market assessment of nanomaterials over a broad range of applications. This report, GM-201B, which is part two of a three-volume series, examines in detail biomedical, pharmaceutical, and cosmetic applications for nanoparticulate materials. The primary objectives of this study are to provide technological background, detailed industry information, and market data and forecasts through 2005, segmented by application and material type.

AUDIENCE FOR THIS REPORT

This report is a valuable resource for companies and organizations that are:

• involved in the commercialization of nanoparticulate materials and looking for new market opportunities;
• interested in incorporating nanoparticles into new or existing products as an end user;
• involved in nanomaterial research and development;
• in search of licensing opportunities for their nanoparticle synthesis or processing technologies;
• seeking partners for their commercialization efforts; and/or are
• looking for venture capital investment opportunities.

SCOPE AND CONTENT OF THIS REPORT

Defined broadly, the term "nanostructured" is used to describe materials characterized by structural features of less than 100 nm in average size. All of the materials discussed in this report are inorganic particulate materials of submicron or nanoscale crystallite sizes. Nanoparticulate ceramics, metals, alloys, and semiconductors in the form of dry powders, liquid dispersions, coatings, and bulk materials are considered. Carbon black powders, fullerenes, and nanotubes are beyond the scope of this study, as are polymeric nanoparticles. Nanotechnology, the building of components atom by atom, and micromachines are not covered here.

The report begins with an Overview chapter that describes the various types and forms of nanostructured materials and their properties, and the surprisingly extensive history of the industry is detailed in a timeline. The Technology chapter presents an overview of vapor phase, wet-chemical, and solid-state techniques in producing nanostructured particles, as well as dispersion, coating, compaction, and self-assembly technologies. Major researchers and institutions involved in nanoparticle studies are identified, and the chapter concludes with an analysis of nanomaterials-related U.S. patents issued during the past 2 years.

The Industry Structure chapter presents a who's-who of the nanomaterials industry. Major and minor companies from the U.S. and around the world are identified and profiled, and nanoparticulate products, pricing, commercialization strategies and competition are discussed. The chapter concludes with the identification of industrial recipients of nanomaterials-related government funding awards during the past decade and a detailed collection of company profiles.

In the World Markets chapter, current and emerging biomedical, pharmaceutical, and cosmetic applications for nanoparticles are identified and analyzed. Within each application area, technological requirements, relevant production technology, companies involved, and the commercial status are discussed. Finally, world markets for nanoparticles in each application area are presented through 2005.

Appendices provide listings of contact information for all of the industry participants, as well as detailed timelines of industry events (including company foundings, moves, expansions, acquisitions, and collaborations), relevant U.S. patent data, and government funding awards.

METHODOLOGY AND INFORMATION SOURCES

The data in this report were obtained from both primary and secondary sources. Executives, engineers, managers, researchers, and salespeople from companies and research institutions involved in the development, production, and/or usage of nanostructured materials were interviewed in the course of this study. Other data were obtained from an exhaustive review of patent literature and government databases, as well as scientific, trade, and journals, and company literature. BCC newsletters, reports, and conferences provided additional information.

ANALYST CREDENTIALS

Mindy N. Rittner, Ph.D., the author of this report, has been studying nanoparticulate materials for nearly a decade, initially as a materials researcher and more recently as a market analyst. In addition to nanomaterials, Rittner follows other growing segments of the materials industry, including metal matrix composites, powder metallurgy, and sputtering target materials. She is the founder and editor of BCC's monthly newsletter, Nanoparticle News, and the program chairwoman of BCC's annual nanopowder conference. Rittner earned her Ph.D. from the Department of Materials Science at Northwestern University.