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DNA Sequencing: Emerging Technologies and Applications

Report Code: BIO045C

Publish Date: Jul 2010

Publisher: BCC Publishing

Category: Cell Biology

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Report Highlights

  • The worldwide market for sequencing products will grow from an estimated $1.3 billion in 2010 to more than $3.3 billion by 2015, a compound annual growth rate (CAGR) of 20.5% over the next 5 years.
  • Life-science research and drug discovery and development applications represent the two largest markets for DNA sequencing revenues, accounting for an estimated $920.1 million in 2010.  These markets are forecast to grow at a compound annual growth rate (CAGR) of 13% to reach nearly $1.7 billion in 2015.
  • Emerging applications, including personal genomics and clinical diagnostics, are forecast to account for $541.4 million by the year 2015, an increase from $15.5 million in 2010 representing a 103.5% compound annual growth rate (CAGR).

 

INTRODUCTION

STUDY GOALS AND OBJECTIVES
 
BCC’s goal for this study is to determine the status of current and newer generation DNA (deoxyribonucleic acid) sequencing technologies, products and services and to assess their worldwide growth potential over a 5-year period from 2010 to 2015. Our particular interest is to characterize and quantify the DNA sequencing products market by application, technology, analysis type, geography, and end user. Sequencing applications market segments that will provide substantial future growth opportunities for next-generation DNA sequencing companies include research, drug discovery and development, bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. Applications providing growth opportunities for genomics suppliers include sequence capture and bioinformatics. 
 
Our main objective is to present a comprehensive discussion of DNA sequencing technologies; industry structure; key applications; major sequencing initiatives; global markets; intellectual property (IP) and patenting status; and sequencing companies. This discussion will assist life-science companies in strategic planning to meet the challenges and opportunities of this dynamic industry.
 
REASONS FOR DOING THE STUDY
 
The Human Genome Project (HGP) moved DNA sequencing technology to the forefront of life-science research as a genetic analysis tool. The HGP relied heavily on Sanger sequencing by capillary electrophoresis to decipher the DNA sequence of the bases in the human genome. A significant outcome of the HGP was improvements in the efficiency and costs of DNA sequencing. During this time period, the DNA sequencing industry consolidated, resulting in one dominant company, Applied Biosystems. 
 
Beginning in 2005, new DNA sequencing technologies have emerged that are radically changing the structure of the industry and opening up exciting new market applications. Contributing to the rise of these new sequencing technologies are advances in nanotechnology, microfluidics, imaging, enzymology, and bioinformatics. Based on these market and technology dynamics, it is timely to examine the future DNA sequencing markets. 
 
Ongoing discoveries in nanotechnology, bioinformatics, microfluidics, imaging, enzymology, and bioinformatics are revolutionizing many life-science fields, and providing novel platforms for next-generation DNA sequencing. At the same time this is occurring, there is a growing market demand for analysis of the genomes of many species and cancers and for understanding the role of genetic variation among individuals in disease. The genetic analysis industry seeks to meet these needs with tools such as microarrays, real-time polymerase chain reaction (RT-PCR), and DNA sequencing instruments. 
 
Next-generation sequencing has created new opportunities to compete with traditional genetic analysis tools, and this report examines this trend and its significance for companies supplying DNA sequencing products and services. 
 
Next-generation, and follow-on, third-generation DNA sequencing technologies will continue to change the dynamics of the DNA sequencing industry and create novel market opportunities. This report analyzes these trends and their impact on the future markets for DNA sequencing technologies.
 
Given the evolving nature of this industry, it is particularly timely to gain an understanding of these technological and competitive forces and the impact on the genetic analysis markets. 
 
INTENDED AUDIENCE
 
We have compiled a study of next- and third-generation technologies that will be commercially important in the major end-user segments of life-science research, drug discovery and development, forensics and human identification, bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. We present both Sanger sequencing and follow-on-generation technologies as well as market growth driving forces, major sequencing initiatives, product formats, market applications, industry alliances, future market potential, and product sales forecasts for the period 2010 through 2015. We forecast the use of sequencing products for these end-user segments: major sequencing centers, academic genome centers, government labs, pharmaceutical/biotech labs, small to mid-size labs, and sequencing service labs.
 
This study will be of particular interest to life-science research tools suppliers, pharmaceutical, diagnostics, nanotechnology, bioinformatics, semiconductor, and biotechnology companies. It will also be valuable to companies involved in genome sequencing projects, sequencing centers, manufacturers of microarrays, suppliers of molecular diagnostics assays, bioinformatics companies, and cancer researchers and clinicians.
 
SCOPE OF REPORT
 
The study scope includes DNA sequencing technologies likely to be commercialized within the next 5 years. Sanger, next-generation, and third-generation technologies are included. Each technology is analyzed to determine its market status, impact on future market segments, and forecast growth from 2010 through 2015. Advantages and limitations of each technology together with market driving forces are discussed.
 
BCC examines the sequencing industry structure, strategic industry alliances and acquisitions, and sequencing patents. The strategies of the main sequencing companies are discussed. The markets for sequencing applications, including de novo whole-genome sequencing, resequencing, ChipSeq, MethylSeq, and RNASeq, are analyzed. 
 
METHODOLOGY
 
BCC surveyed key users and producers in each of the market applications that will be commercially important during the next 5 years: research, drug discovery and development, forensics and human identification (ID), bacterial genomics, agricultural genomics, clinical diagnostics, and personal genomics. Based on our industry discussions and market analysis, we project the future applications of sequencing platforms and forecast sales revenues for 2010 through 2015.
 
The sequencing market is analyzed by technology, product type, application, customer, analysis type, geography, and genome type, with forecasts of market demand from 2010 through 2015. We analyze which applications and analyses will be important to the future of DNA sequencing, and the customer groups that will be consumers of the technologies. We also analyze the impact of other genetic analysis technologies like microarrays on the growth of sequencing.
 
INFORMATION SOURCES
 
BCC surveyed leading DNA sequencing, biotechnology, and nanotechnology companies as well as core sequencing facilities and laboratories to obtain data for this study. Included were research tools, drug, biotechnology and nanotechnology firms, and leading life-science research institutions. We also spoke with leading industry thinkers. In addition, we compiled data from secondary sources, including industry, trade, and government.
 
ANALYST CREDENTIALS
 
The author, John Bergin, has written previous BCC Research biotechnology reports, titled Epigenomics: Emerging Opportunities in Biomarkers, Diagnostics and Therapeutics; Global Biochip Markets: Microarrays and Lab-on-a-Chip; RNA Interference in the Post-Genomics Era: Markets and Technologies; Synthetic Biology: Emerging Global Markets; Biologic Imaging Reagents: Technologies and Global Markets. Mr. Bergin has held business development, sales, and marketing positions with a Fortune 500 advanced materials company as well as executive management positions with a nanotechnology company. Mr. Bergin holds the following degrees: B.S. Chemistry, M.S. Biotechnology, and Masters of Business Administration. 
 
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DISCLAIMER

The information developed in this report is intended to be as reliable as possible at the time of publication and of a professional nature. This information does not constitute managerial, legal, or accounting advice; nor should it serve as a corporate policy guide, laboratory manual, or an endorsement of any product, as much of the information is speculative in nature. The author assumes no responsibility for any loss or damage that might result from reliance on the reported information or its use.

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Table of Contents

All reports provided in PDF format. For shared licensing options (5+ Users), please call a representative at (+1) 781-489-7301 or contact us at info@bccresearch.com
[+] Show Chapter Details
Title/Chapter NamePagesMember Price
Full Report: DNA Sequencing: Emerging Technologies and Applications297Free
Chapter- 1: INTRODUCTION4Free
Chapter- 2: EXECUTIVE SUMMARY3Free
Chapter- 3: OVERVIEW10Free
Chapter- 4: DNA SEQUENCING TECHNOLOGIES58Free
Chapter- 5: DNA SEQUENCING APPLICATIONS26Free
Chapter- 6: DNA SEQUENCING INITIATIVES29Free
Chapter- 7: DNA SEQUENCING INDUSTRY STRUCTURE40Free
Chapter- 8: DNA SEQUENCING MARKETS42Free
Chapter- 9: DNA SEQUENCING PATENT STATUS16Free
Chapter- 10: C. CRAMER & CO. GMBH69Free

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This is an Excel-only version of the report.

Report Includes

    Total Number of Tables in this Report: 69

  • Summary Table: GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, THROUGH 2015
  • Table 1: SCOPE OF THIS REPORT
  • Table 2: GLOBAL VALUE OF DNA SEQUENCING WORKFLOW PRODUCTS, BY TYPE, THROUGH 2015
  • Table 3: DNA SEQUENCING KEY GROWTH DRIVING FORCES
  • Table 4: PRODUCT LIFE CYCLE STATUS OF SEQUENCING PLATFORMS
  • Table 5: SEQUENCING INSTRUMENT COMPETITORS, BY TECHNOLOGY
  • Table 6: SCOPE OF KEY GENETIC ANALYSIS TECHNOLOGIES
  • Table 7: DNA SEQUENCING HISTORICAL TIMELINE
  • Table 8: DNA SEQUENCING TECHNOLOGY PLATFORM COMPARISON
  • Table 9: LIMITATIONS OF SANGER SEQUENCING TECHNOLOGY
  • Table 10: IMPROVEMENTS IN SANGER SEQUENCING TECHNOLOGY
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Report Highlights

  • The global DNA sequencing industry was worth $794.1 million in 2007. This is expected to reach $862.5 million in 2008 and $1.7 billion in 2013, a compound annual growth rate (CAGR) of 14.7%./li>
  • Research and drug discovery/development generated global revenues of $600.4 million in 2007. This is expected to increase to $640.6 million in 2008 and $1.0 billion in 2013, for a CAGR of 9.7%.
  • Commercial applications were valued at $193.6 million in 2007 and an estimated $218.8 million in 2008. This segment should reach $426.1 million in 2013, a CAGR of 14.3%.
Published - May-2005| Analyst - Ralph Hensler| Code - BIO045A

Report Highlights

  • Projected sales for the worldwide DNA sequencing and proteomics markets are expected to rise at an AAGR (average annual growth rate) of 17.6% from $7.8 billion in 2004 to $17.5 billion in 2009.
  • Drug discovery and healthcare currently are two of the largest market sectors, representing respectively, some 46% and 20% of revenues in 2004.
  • The food and renewable resource sector will grow at a modest pace motivated by the production of genetically altered food products offering better nutritional benefits and lower product costs.
  • The environment market sector has only begun to tap into the technology benefits and this basic research sector will grow given the possibility of new research fields that may emerge.

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