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Regenerative Medicines: Bone and Joint Applications

Report Code: PHM032B

Publish Date: Oct 2009

Publisher: BCC Publishing

Category: Pharmaceuticals

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Report Highlights

  • Overall sales in the regenerative medicine productsmarket were worth $1.1 billion in 2007, and remained flat into 2009. By 2014, sales are projected to increase to nearly $1.8 billion, for a 5-year compound annual growth rate (CAGR) of 8.6%.
  • The largest segment in the market, bone replacement/grafting, was valued at $714  million in 2007. This also has increased only slightly into 2009 but is projected to reach $979  million in 2014, for a 5-year CAGR of 6.3%.
  • Sales in the bone growth stimulators product segment were worth $321  million in 2007, and were to increase slightly into 2009.  By 2014, however, they are projected to increase to $578  million, for a 5-year CAGR of 11.9%.

INTRODUCTION 

Regenerative medicine is a relatively large and rapidly evolving segment of the healthcare business. The regenerative medicine industry has been in existence for nearly 25 years. Actual product sales, along with research and development (R&D) expenditures, are projected to amount to approximately $2 billion in economic activity in 2009. Bone and joint applications account for a little more than half of those revenues, or $1.2 billion. The rapid evolution of this business is evidenced by the industry consolidation that has occurred since the first edition of this BCC Research report was published in 2003. In addition, intensive R&D efforts at universities and the National Institutes of Health that focus on cutting-edge technology underscore the importance of this industry.
 
The key objective of regenerative medicine is the utilization of living cells to repair or replace body tissue damaged by injury, disease, or the aging process. The most successful products have drawn upon multidisciplinary fields such as biology, medicine, engineering, and particularly biomedical engineering. The principal focus in this report is on bone and joint applications; however, other regenerative applications such as dental, neurologic, organ regeneration, cardiovascular, urologic, diabetes, and wound care are important. Stem-cell research is an important component of the sector as well. For example, the successful differentiation of embryonic stem cells into specific cell types is widely sought as a means to treat traumatic spinal-cord injury, as well as diseases such as diabetes, Duchenne muscular dystrophy, heart disease, and vision and hearing loss.
 
OBJECTIVES AND GOALS OF STUDY
 
This report focuses on the bone- and joint-related applications and markets for the various categories of regenerative medicine products currently available and projected to be introduced during the 5-year forecast period from 2009 to 2014. Market drivers discussed include an increase in diseases and disorders that will benefit from these products, primarily arthritis, osteoporosis, and various types of bone and joint trauma (e.g., hip fractures, knee injuries); increasing use of non-autograft products by physicians; and innovative devices that incorporate bone- and cartilage-growth-stimulating agents in a regenerative appliance. Products discussed include bone and cartilage grafting and regenerative products derived from autologous, allogeneic, and synthetic sources, as well as electrical stimulators for bone growth and regenerative cartilage products.
 
Profiles are provided of leading and emerging companies in the bone and joint regenerative medicine markets, along with analyses of the current and future positioning of their products and businesses in this active and rapidly changing market.
 
INTENDED AUDIENCE
 
The aim of this report is to provide an overview of regenerative medicine products, both available and emerging, for the treatment of diseases and disorders of the bones and joints. The information and analysis presented are important assets in decision making for managers involved in business development, marketing, market research, product development, mergers and acquisitions, licensing, business management, investment banking, and deal creation, as well as to consultants to the pharmaceutical and biotechnology industries. The study provides a comprehensive analysis of the current markets for regenerative medicine products for bones and joints, relevant applications, and the potential of products in development.
 
SCOPE OF REPORT
 
The U.S. has been the main regenerative medicine market both in terms of R&D innovation and product sales; hence, the scope of the study is mainly U.S., although worldwide developments are discussed where relevant. The Overview section provides a background of the demographics underlying the market for bone and joint products, a definition of regenerative medicine and the technologies involved, and a discussion of regenerative products in development for applications other than bones and joints. Various applications sections describe the leading bone and joint diseases and disorders applicable to regenerative technologies, including incidence and current methods of treatment.
 
The section on Products provides extensive descriptions and analyses (e.g., comparative analysis) of regenerative products used to treat bone and joint disorders, as well as a discussion of products in development.
 
The section on FDA clinical trials and newly approved products provides a discussion of regulatory issues affecting regenerative medicine products.
 
An extensive Company Profiles section provides a concise exploration of leading and emerging companies in the area of regenerative products for bones and joints, including product introductions, patents, and overall business strategies.
 
METHODOLOGY
 
Both primary and secondary research methodologies were used to prepare this market research report. The base year for this study is 2009. Sales data are estimated in nominal dollars (unadjusted for inflation). Information to prepare this study was derived from market intelligence provided by chief executive officers, marketing strategists, research executives, and others at leading companies involved in the regenerative medicine market. Data was accessed from government agencies and regulatory bodies that monitor and/or regulate medical devices. Searches of secondary material such as company annual reports and 10Ks, journal articles, prospectus assessments, government resources, and data from healthcare institutions were conducted.
 
INFORMATION SOURCES
 
The information and analyses presented in this report are based on an extensive survey of the biotechnology and pharmaceutical industries, as well as a detailed examination of published literature and reports obtained from regulatory authorities, medical research institutions, pharmaceutical trade associations, and national and world health organizations.
 
ANALYST CREDENTIALS
 
Research analyst Kevin Gainer holds both B.A. and M.A. degrees in quantitative economic analysis, and has 25 years of economics and market research experience. He is the author of five published books; dozens of technical papers, analyses, and studies published in conference proceedings; and many unpublished reports within corporations. He has worked as a Research Editor and Project Analyst at BCC Research and over the last 25 years has authored many BCC technology market research reports.
 
BCC ONLINE SERVICES
 
BCC offers an online information retrieval service. BCC’s home page, located at www.bccresearch.com, enables readers to:
 
·          Examine BCC’s complete catalog of Market Research Reports and place direct orders
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·          Read announcements of recently published reports and newly launched newsletters
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·          Request additional information on any BCC product
·          Take advantage of special offers
 
 
DISCLAIMER
 
The information developed in this report is intended to be as reliable as possible at the time of publication and of a professional nature. This information does not constitute managerial, legal, or accounting advice; nor should it serve as a corporate policy guide, laboratory manual, or an endorsement of any product, as much of the information is speculative in nature. The author assumes no responsibility for any loss or damage that might result from reliance on the reported information or its use.
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Table of Contents

All reports provided in PDF format. For shared licensing options (5+ Users), please call a representative at (+1) 781-489-7301 or contact us at info@bccresearch.com
[+] Show Chapter Details
Title/Chapter NamePagesMember Price
Full Report: Regenerative Medicines: Bone and Joint Applications269Free
Chapter- 1: INTRODUCTION4Free
Chapter- 2: SUMMARY2Free
Chapter- 3: OVERVIEW AND OVERALL STATUS OF THE INDUSTRY11Free
Chapter- 4: PRINCIPLE APPROACHES TO REGENERATIVE MEDICINE13Free
Chapter- 5: PRODUCTS AND TECHNOLOGIES: CATEGORIES OF REGENERATIVE MEDICINE 18Free
Chapter- 6: STEM CELL THERAPIES AND REGENERATIVE MEDICINE18Free
Chapter- 7: REGENERATIVE PRODUCTS TO TREAT BONE DISEASES33Free
Chapter- 8: REGENERATIVE APPLICATIONS FOR BONES AND JOINTS35Free
Chapter- 9: ELECTRICAL BONE GROWTH STIMULATOR MARKET8Free
Chapter- 10: ORTHOPEDICS—FDA CLEARANCES AND NEW PRODUCT DEVELOPMENT 16Free
Chapter- 11: MARKET FOR TISSUE ENGINEERING PRODUCTS4Free
Chapter- 12: REGENERATIVE CONCEPTS AND PRODUCTS IN DENTISTRY3Free
Chapter- 13: SKIN TECHNOLOGIES3Free
Chapter- 14: NEUROLOGICAL APPLICATIONS IN REGENERATIVE MEDICINE4Free
Chapter- 15: REGENERATIVE MEDICINE AND APPLICATIONS IN CARDIAC CARE6Free
Chapter- 16: REGENERATIVE MEDICINE AND DIABETES2Free
Chapter- 17: FDA APPROVED CLINICAL TRIALS INVOLVING REGENERATIVE MEDICINE29Free
Chapter- 18: OVERSEAS ACTIVITIES3Free
Chapter- 19: PATENT ANALYSIS5Free
Chapter- 20: C. CRAMER & CO. GMBH45Free
Chapter- 21: GLOSSARY OF KEY TERMS IN REGENERATIVE MEDICINE BUSINESS7Free

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This is an Excel-only version of the report.

Report Includes

    Total Number of Tables in this Report: 44

  • Summary Table: U.S. MARKET FOR REGENERATIVE MEDICINE PRODUCTS USEDIN BONE AND JOINT APPLICATIONS, THROUGH 2014
  • Table 1: FUNCTIONAL ACTIVITIES WITH REGENERATIVE MEDICINE SECTOR
  • Table 2: PRINCIPAL REGENERATIVE MEDICINE BUSINESS R&D FOCUSES
  • Table 3: 20-YEAR PLANNING HORIZON FOR REGENERATIVE MEDICINE BUSINESS: LIKELY DEVELOPMENTS, 2015-2030
  • Table 4: PRINCIPLE RESEARCH PROJECTS OF CIMIT IN THE TISSUE-ENGINEERING AND BIOMATERIALS FIELDS, 2008-2010
  • Table 5: COMMERCIAL SUPPLIERS OF BIOREACTORS FOR USE IN REGENERATIVE MEDICINE
  • Table 6: BONE MORPHOGENETIC PROTEINS
  • Table 7: U.S. MARKET FOR TISSUE-ENGINEERED CARTILAGE PRODUCTS,THROUGH 2014
  • Table 8: FEDERAL FUNDING FOR STEM CELL RESEARCH, THROUGH 2008
  • Table 9: STATE LEVEL PROGRAMS FOCUSED ON STEM CELL RESEARCH
  • Table 10: CHARACTERISTICS OF IDEAL BONE GRAFT MATERIAL
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Report Highlights

  • The total U.S. market for bone and joint applications of regenerative medicine is projected to rise at an average annual growth rate of 8.5% to reach $1.4 billion in 2007.
  • Regenerative medicine refers to technologies that repair or replace diseased or defective tissues or organs. The main types of regenerative medicine utilize products naturally occurring in the body, such as genes and proteins (antibodies, growth factors, hormones); cells and tissues; embryonic stem cells, and biomaterials. At present, most regenerative medicines on the market fall into the first category and include protein-based drugs and therapies containing human cells. However, there are a few products based on tissue engineering. This technology, which promises to be the most exciting and fastest growing sector of regenerative medicine in the near future, is the primary focus of this report. Tissue engineering technologies discussed include matrices and scaffolds, in vitro and in vivo technologies, and novel materials, which include those utilizing nanotechnology (atomic-scale engineering) of inorganic substances that meld with human tissues.

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