APPLIED STEMCELL

Company Overview

Established in 2008, Applied StemCell is a biotechnology company with the mission of advancing gene-editing and stem cell innovation for biomedical research. The company offers a series of tools for basic research study, drug discovery, bioprocessing, bio-production, and preclinical applications.

The company is currently focusing on four areas:

• Stem cell-based services and products to build next-generation cell line models and to advance cell-based therapies.
• Physiologically predictive animal model generation and downstream in vivo assays for model validation and drug screening.
• Gene-expression technology in cell lines for library screens, bio-production and bioassays.
• Pre-IND enabling gene and cell therapy bio services CRO with service from model generation to efficacy/toxicology studies, potency assay, pre-IND filing, and chemistry, manufacturing, and controls (CMC) consultation. 

Using its proprietary TARGATT gene modification technology and its licensed CRISPR technology, the company generates site-specific knock-in rat, mouse, and human cell line models for the pharmaceutical and academic research communities.

The company offers a large array of products for site-specific transgenics, cell culture, and stem cell research. The company’s products encompass a broad spectrum, from high-quality transgenic kits for knock-in mice and knock-out mice generation, mouse embryonic fibroblast cells, feeder cells, growth factors, and options for stem cell characterization and stem cell differentiation, as well an array of iPSCs. The company offers iPSCs, iPSC-derived cells, reprogramming/ differentiation kits, and supplements, among many other products.

Company's Business Segments

• Stem Cell Products : GMP Grade iPSCs, iPSC Lines, iPSC Differentiated Cell Products, MEF Feeder Cells, Primary Cells and Tissues.
• Stem Cell Services : iPSC Gene Editing, iPSC Differentiation Cell Services, iPSC Generation Services, Cell-Based Assays.
• CRO/CDMO : cGMP Cell Manufacturing and Cell Banking, GMP Plasmid Manufacturing, Process and Analytical Development, Quality Management & Regulatory.
• Tissue Samples and Primary Cells : Humanized Mouse Models | Off-the-shelf, Teratoma Formation, CAR-T/NK and Biologics Efficacy Studies, Biodistribution, PD and PK Studies.