| Year | Detail |
| 1999 |
Cell Signaling Technology (CST) is a privately held company headquartered in Danvers, Massachusetts, U.S., founded in 1999 by Michael Comb. |
| 2008 |
Cell Signaling Technology, Inc., and TTP LabTech collaborated to develop and co-market Antibodies and Acumen Cytometric Assay Solutions for high-content screening and drug discovery. |
| 2009 |
The company acquired BIOKÉ, B.V., and expanded operations in Europe. |
| 2012 |
The company develops a novel Monoclonal Antibody Discovery platform. This technology enables the isolation of monoclonal antibodies with antigen-specific activities that recapitulate or surpass those of the original affinity-purified polyclonal antibodies found in the sera of immunized rabbits and mice. |
| 2013 |
The company was granted a patent for PCR Methods to detect a subset of treatable Non-Small Cell Lung Cancers. |
| 2014 |
Dako, an Agilent Technologies company, partnered with Cell Signaling Technology to supply antibodies for Dako-branded companion diagnostics products. |
| 2018 |
The company opened a new office in Shanghai, China. The new facility triples the office and warehouse footprint and features CST's Global Innovation and Training Academy. |
| 2023 |
The company agreed with Roche to develop and commercialize CDx assays using CST antibodies. |
| 2023 |
The company partnered with Bio-Techne Corp. to expand the menu of Simple Western-validated antibodies for various targets across multiple disciplines. |
| 2023 |
Lunaphore partnered with Cell Signaling Technology Inc. to enable CST antibodies on the Lunaphore COMET platform. |
| 2023 |
The company partnered with Leica Biosystems, a technology company in automated staining and brightfield and fluorescent imaging, to support the development of companion diagnostics (CDx) assays using the extensive portfolio of antibodies from CST validated for immunohistochemistry (IHC). |
| 2023 |
Shanghai WuXi Diagnostics Co.Ltd and Cell Signaling Technology have partnered to develop targeted companion diagnostics (CDx). |