| Year | Detail |
| 1872 |
Leica Biosystems Nussloch GmbHestablished as Precision Engineering company. |
| 1873 |
It Published catalog markets a comprehensive product range in microtomy. |
| 1914 |
Started manufacturing small munitions. |
| 1928 |
Published first edition of a Japanese‑language Jung microtome catalog. |
| 1936 |
Introduced new microtomy offerings including the electric object cooling FRIGOMAT and the electric knife cooling FRIGOTOM. |
| 1968 |
The company was transferred to the U.S.‑based Warner‑Lambert Corporation.The companies Reichert (Vienna) and Jung (Nussloch). |
| 1985 |
Introduced a suite of new product designs at the Analytica trade show in April 1985. |
| 1986 |
Cambridge Instrument Ltd. took over R. Jung GmbH. |
| 1989 |
The Leica Group is formed from themerger of the WILD LEITZ Group with the Cambridge Instruments Company. |
| 1991 |
Partnership established with the Australian Biomedical Company. |
| 1993 |
Partnership established with Japan‑based Sakura Finetek. |
| 1997 |
The Leica Group organizes into three independent companies: Leica Camera AG in Solms; Leica Geosystems AG in Heerbrugg, Switzerland; and Leica Microsystems in Wetzlar. |
| 1998 |
Leica Microsystems is acquired by investment company Schroders Ventures. |
| 1999 |
Established a joint venture with Eastern Europe‑based Feintechnik Eisfeld to manufacture microtome blades in‑house. |
| 2000 |
Introduced the disk microtome Leica DSC1. |
| 2002 |
Introduced the first‑in‑class printers IP S (Sakura Autowrite S) and IP C (Sakura Autowrite C). |
| 2005 |
Leica Microsystems is acquired by U.S.‑based Danaher Corp. |
| 2008 |
Acquired U.S.‑based Coretech, Surgipath. |
| 2009 |
Acquired U.K.‑based Genetix. |
| 2014 |
Acquired Devicor. |
| 2015 |
The HistoCore Spectra ST is introduced. |
| 2019 |
The company organizes into two Business Units: Core Histology and Advanced Staining and Imaging. |
| 2021 |
The AI and Machine Learning Strategic Business Unit (SBU) is established. |
| 2022 |
Introduced BOND‑PRIME, a premium Advanced Staining solution to advance diagnostic productivity in the lab. |