| Year | Detail |
| 1935 |
Yakult was established by Dr. Minoru Shirota in Japan. |
| 1940 |
Local offices of the Association for Promotion of Preventive Bacteria Strain Shirota are established in various parts of Japan for the purpose of marketing and distributing Yakult. |
| 1955 |
Yakult Honsha Co., Ltd. was established (Nishi Hatchobori, Chuo-ku, Tokyo), and the Research Institute was established in Kyoto. |
| 1963 |
Yakult launches its unique Yakult Lady home delivery system. |
| 1964 |
Yakult Taiwan Co., Ltd. begins operations as the company’s first overseas operation base. |
| 1967 |
The research institute is established in Kunitachi, Tokyo (later known as Yakult Central Institute). |
| 1968 |
The company has been introduced to the market in a new plastic container. |
| 1970 |
Yakult Honsha introduced Joie fermented milk to the market. |
| 1971 |
The company begins the full-scale sale of cosmetics. |
| 1975 |
Biolactis Capsules, an ethical drug, is introduced to the healthcare industry, thereby marking Yakult's entrance into the pharmaceutical business. |
| 1978 |
Yakult Honsha has introduced Mil-Mil bifidobacteria-fermented milk to the market. |
| 1979 |
Yakult Seichoyaku intestinal regulator, an over-the-counter medicine, is introduced to the healthcare industry. |
| 1980 |
Company stocks are listed in the second section of the Tokyo Stock Exchange, and Toughman is introduced to the market. |
| 1981 |
Company stocks are listed on the First Section of the Tokyo Stock Exchange. |
| 1989 |
The company had launched the Revecy S.E. Series in the market. |
| 1992 |
Yakult Bioscience Research Foundation is established. |
| 1994 |
The manufacture of irinotecan hydrochloride, a cancer chemotherapeutic agent, is approved, and the drug is introduced to the healthcare industry under the brand name Campto. |
| 1995 |
Parabio Series premium-quality skincare product line is introduced to the market. |
| 1998 |
Yakult is approved by the Ministry of Health and Welfare for labeling as Foods for Specified Health Uses. Yakult Bansoreicha is introduced to the market. |
| 1999 |
Yakult Honsha launched the Yakult 400 fermented milk drink in the market. |
| 2004 |
The company had entered into a strategic alliance with Groupe Danone. |
| 2005 |
Research center is established in Europe (Belgium) and Oxaliplatin, a cancer chemotherapeutic agent for the treatment of advanced colorectal cancer, is approved under the name of Elplat. |
| 2006 |
The name of Yakult’s cosmetics brand has been changed to Yakult Beautiens. |
| 2011 |
The three-dimensional trademark for Yakult containers is recognized. |
| 2012 |
Yakult launches the Yakult Space Discovery Project. |
| 2013 |
Lactobacillus casei strain Shirota obtains GRAS Certification from the US FDA (Food and Drug Administration). New Yakult and New Yakult Calorie Half are introduced to the market. |
| 2019 |
Yakult Honsha launched the Yakult 1000 in the seven prefectures of the Kanto region. |
| 2020 |
The head office is relocated to Kaigan, Minato-ku, Tokyo. |
| 2021 |
Yakult 1000 and Yakult 400W is launched nationwide in Japan. |
| 2022 |
The company's shares are listed on Prime Market following the reorganization of stock market categories by the Tokyo Stock Exchange. |
| 2023 |
Yakult Honsha launched products for companion animals (pets) using Yakult's unique galacto-oligosaccharide. |