DEPIXUS

Company Overview

Depixus is developing and marketing a unique technology for obtaining sequence information. Depixus’ Single Molecule Mechanical Detection and Quantification (SIMDEQ) platform uses biophysical methods to determine sequencing information.

In SIMDEQ, fragments of DNA are converted into a hairpin library. One end of each hairpin is bound to the surface of a flow-cell and the other end is attached to a small magnetic bead. When the beads are placed in a magnetic field, the DNA is stretched upward. The distance to the magnetic bead can be measured from optical interference rings. Changes in the hairpin loop can be induced by binding querying oligonucleotides, which provide sequencing information. Multiple probes can be used at the same time for higher-throughput applications.

The advantage of this technology over conventional NGS is that a wide range of DNA modifications can be identified, including complex repeats, large insertions and deletions, and other chromosomal structures. Applications include detecting triplet repeat diseases and DNA fingerprinting.

In December 2021, Depixus raised EUR 30.6 million in oversubscribed Series A funding led by Lansdowne Partners. This funding will further aid the company to develop its proprietary MAGNA instrument system, workflows, and reagents for commercial release.

Company's Business Segments

• Spectroscopy Technology : This segment of the company includes pioneering a Cutting-edge Magnetic Force Spectroscopy Technology to unveil the Intricate World of Molecular Interactions.