SYNVIVO INC.

Company Overview

Synvivo Inc offers an Alabama based company that focuses on cell-based microfluidic organ-on-chip platform.It delivers a biologically authentic microenvironment for real-time investigations into cellular behavior, drug delivery, and drug discovery. This proprietary technology amalgamates the realms of microfluidics and bioengineering, catering to diverse life science applications. SynVivo’s exclusive microfluidic chips support a microvascular network, mimicking tissue circulation concerning flow, shear, and pressure dynamics. Human cells cultured within SynVivo chips maintain biological phenotypes like those observed in tissues.

The SynVivo Cancer Chip, the first in a new line of chips that the company is commercializing for personalized medicine applications, uses tumor biopsy cells to rapidly recapitulate the patient’s tumor microenvironment for testing drugs and drug combinations. This technology allows drugs to be tested within days of receiving a biopsy, providing timely feedback to the patient and oncologist exploring therapeutic options. SynVivo has developed a microfluidics-based cancer chip that uses the patient’s own tumor cells to create a screening device that closely reflects the microenvironment of the patient’s tumor. SynVivo’s technology differentiator is the ability to design and fabricate a chip capable of supporting a microvascular network that includes the blood flow in and around the tumor, and the ‘leaky’ endothelium typically found inside the tumor vasculature. This is achieved by first establishing a confluent layer of vascular endothelial cells inside the chip and then cells from a patient’s tumor biopsy are introduced, which form a 3D tumor mass.

Company's Business Segments

• 3D Tissue and Organ-on-Chip Models : This segment is a Cell-based Microfluidic Organ-on-Chip Platform that provides a Biologically Realistic Microenvironment for the real-time study of Cellular Behavior, Drug Delivery, Drug Discovery.