Biotech 2010

Published - Jun 2006| Analyst - Valarie Natale| Code - BIO054A
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Report Highlights

  • The area most likely to see strong growth in the next five years involves collaborations between large and small companies. Such collaborations were worth $13 billion in 2005, will increase to $14.4 billion in 2006 and reach $22 billion in 2010. Small biotechnology and device companies provide innovative drug candidates and other products to larger companies wishing to fill pipelines or expand into new therapeutic areas.
  • Today, venture capitalists prefer an overall strategy of investing in companies with late-stage projects. Therapeutic agents that have reached Phase II or Phase III clinical trials are most attractive. Venture capital for biotechnology amounted to $3.7 billion in 2005 and will reach $3.9 billion in 2006. This will increase $4.6 billion in 2010.
  • Factors influencing the growth of the life sciences market include the continuing investments of national governments, the push by big pharmaceutical companies to fill their blockbuster pipelines, and efforts by small biotechnology companies to become bigger companies. As all of these groups continue their efforts, they will, in turn, drive the development of new instruments and new technologies.

INTRODUCTION

The life sciences industry is going through a period of significant change. A small number of the younger companies, such as Amgen, Genentech, and Genzyme, have grown into large multibillion-dollar businesses offering novel therapeutic agents for a variety of disorders. Some of these companies have adopted strategies involving mergers and acquisitions and collaborations with smaller companies, in addition to forming collaborations with the older pharmaceutical giants.

At the same time, the older large pharmaceutical companies, such Merck and Pfizer, are facing lawsuits, challenges resulting from dwindling pipelines, threats from generics, and a national movement to reduce the prices of pharmaceutical agents - not to mention the challenges posed by Canadian pharmacies that sell to U.S. citizens. These situations are a significant threat to the profitability of the large pharmaceutical companies, and how well they meet them will be a large factor in their continued success.

In the middle of these two groups are the smaller companies. For the most part, these companies have novel approaches to drug or target discovery, as well as a supply of early stage therapeutic candidates. The vast majority, however, do not have the resources to develop their products through to commercialization, much less the capital needed to market them effectively.

The approaches employed by these groups to meet their various goals are a primary focus of this report. Also presented are case studies of business approaches that once looked viable, but soon turned sour. Notable companies in this category include DoubleTwist, Celera Genomics, and Incyte Genomics, all of which were founded as information providers, and all of which were undermined by backlashes from researchers and the growth of public databases. Bioinformatics and systems biology are two other areas with great potential but limited abilities (at this time) to shorten drug discovery times and costs.

SCOPE OF STUDY

This report:

  • Analyzes the newly emerging industry in proteomics.
  • Provides an overview of the market and a brief discussion of relevant scientific principles.
  • Discusses current and future investment trends for the U.S. and the importance of each new method of research to the overall market.
  • Analyzes patents and their importance to the industry.
  • Considers investment by angel investors and venture capitalists, collaborations and mergers and acquisitions.
  • Examines the relative merits of systems biology, a new approach and potential "next big thing" in the industry.
  • Presents appendices that contain directories of companies and investors, as well as profiles of companies given significant coverage in the report.

METHODOLOGY AND INFORMATION SOURCES

The material for this report was gathered from interviews with individuals in the industry, as well as a thorough review of technology gathered from secondary sources. These sources include company annual, 10K and 10Q reports, company literature, trade literature, trade associations, and online sources.

Projections were based on current and historical levels of funding and revenues, potential end users, likely unit prices, and rates of consumption. Final projections are based on the analysis of information from primary and secondary sources. All dollar projections are presented in year 2006 constant dollars.

ABOUT THE AUTHOR

Valerie Natale has an M.Sc. in microbiology from the University of Dublin and a Ph.D. in cell biology from the University of Bern. She has considerable experience in biotechnology, both as a research scientist and as the president of a small startup company investigating treatments for neurological disorders. She has written a number of other BCC reports on this industry.

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